Detalhe da pesquisa
1.
Phase 1 Single Ascending and Multiple Ascending Dose Studies of Phosphodiesterase-9 Inhibitor E2027: Confirmation of Target Engagement and Selection of Phase 2 Dose in Dementia With Lewy Bodies Trial.
Alzheimer Dis Assoc Disord
; 36(3): 200-207, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35700341
2.
Design, synthesis and structure-activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists.
Bioorg Med Chem Lett
; 22(14): 4756-61, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22683343
3.
Design, synthesis, and structure-activity relationships of a series of 2-Ar-8-methyl-5-alkylaminoquinolines as novel CRF1 receptor antagonists.
Bioorg Med Chem Lett
; 22(17): 5372-8, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22871582
4.
Synthesis and structure-activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists.
Bioorg Med Chem
; 20(22): 6559-78, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23062820
5.
Selective corticotropin-releasing factor 1 receptor antagonist E2508 reduces restraint stress-induced defecation and visceral pain in rat models.
Psychoneuroendocrinology
; 75: 110-115, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27810704
6.
Selective corticotropin-releasing factor 1 receptor antagonist E2508 has potent antidepressant-like and anxiolytic-like properties in rodent models.
Behav Brain Res
; 312: 138-47, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27297028
7.
N-type calcium channel alpha1B subunit (Cav2.2) knock-out mice display hyperactivity and vigilance state differences.
J Neurosci
; 23(17): 6793-7, 2003 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12890773
8.
Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.
BMC Neurosci
; 6: 33, 2005 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15876356
9.
Increased glucose tolerance in N-type Ca2+ channel alpha(1B)-subunit gene-deficient mice.
Int J Mol Med
; 15(6): 937-44, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15870896
10.
Ca(2+) channel alpha(1B) subunit (Ca(V) 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system.
Trends Cardiovasc Med
; 12(6): 270-5, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12242051
11.
Increased expression of P/Q-type Ca2+ channel alpha1A subunit mRNA in cerebellum of N-type Ca2+ channel alpha1B subunit gene-deficient mice.
Brain Res Mol Brain Res
; 124(1): 79-87, 2004 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-15093688
12.
Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.
Neurosci Lett
; 359(1-2): 37-40, 2004 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15050706
13.
Effect of genetic background on Cav2 channel alpha1 and beta subunit messenger RNA expression in cerebellum of N-type Ca2+ channel alpha1B subunit-deficient mice.
Comp Med
; 54(6): 690-4, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15679268
14.
Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor.
J Med Chem
; 55(11): 5255-69, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22587443
15.
Design, synthesis, and structure-activity relationships of novel pyrazolo[5,1-b]thiazole derivatives as potent and orally active corticotropin-releasing factor 1 receptor antagonists.
J Med Chem
; 55(19): 8450-63, 2012 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22971011